王长山（Changshan Wang），         日本千叶大学医学博士，现任44118太阳成城集团教授、博士生导师、课题组长，内蒙古自治区“草原英才”高层引进人才，tyc1286太阳成集团高层次引进人才。并兼任东京大学医科学研究所（The Institute of Medical Science, The University of Tokyo）外国人特别客座研究员（Visiting fellow）和日本千叶大学医学研究院(The Graduate School of Medicine and School of Medicine)外国人特别客座研究员（Visiting fellow）。同时兼任，美国血液学会会员、国际干细胞学会会员、日本血液学会会员、中国细胞生物学学会会员、中国抗癌学会会员、内蒙古细胞生物学学会常务理事、内蒙古分子临床诊断学会副理事长等学术职务。另外，担任干细胞内蒙古自治区工程研究中心&银宏生命科技健康产业园科技创新中心，特聘专家，高级学术顾问教授；内蒙古民族大学附属医院，特聘教授（Distinguished Professor），博士生导师。还担任国际期刊《Global Journal of Life Sciences 》执行主编（Managing Editor）。曾经担任过，Japan Science and Technology Agency（JST）研究助手（Research Assistant）和Radiation Effects Research Foundation（RERF）协力研究员（Collaborative Researcher）。

2013年毕业于日本国立千叶大学医学部尖端分子医学专业，获医学博士学位。之后在千叶大学医学研究院做博士后研究。2016年3月正式回国加盟44118太阳成城集团工作。

王长山博士长期以来致力于造血干细胞及白血病干细胞的分子生物学，细胞生物学研究。重心集中在基于动物模型和细胞模型，研究 Polycomb group(PcG) 蛋白复合体介导的表观遗传学调控机制。 并在《blood》，《Journal of Experimental Medicine》，《Nature communications》，《Journal of clinical investigation》等国际知名学术期刊上第一作者身份发表6篇高水平论文。同时参与完成《Nature Genetics》等学术期刊上发表14篇高水平学术论文。

Email：changshanwang@imu.edu.cn

Mobile Phone: 15148066197

实验室：生命科学楼4F（404室，406室）

办公室：生命科学楼4F（439室）

 

主要研究领域

 

干细胞生物医学

 

主要研究方向：

 1.造血干细胞命运决定、干性维持、自我更新和体外扩增的分子机制及临床转化研究  

2.微环境与肿瘤干细胞干性调节的表观遗传学机制研究 （肝脏模式、肺脏模式和血液系统模式）

3.组织器官修复再生的细胞与分子机制研究

4.组织干细胞衰老与抗衰老分子机制及age-related disease发生发展的分子机制研究

5.高通量筛选促进人类组织干细胞体内体外扩增功能的小分子化合物

6.组蛋白共价修饰在精原干细胞干性维持中的表观遗传调控作用及机制研究

 

学术论文：

2019年: 

Baojiang Wu, Lin Li, Bojiang Li, Junpeng Gao, Yanglin Chen, Mengyi Wei, Zhiqing Yang, Baojing Zhang, Shudong Li, Kexin Li*, Changshan Wang*, M. Azim Surani, Xihe Li,Fuchou Tang , and Siqin Bao. Activin A and BMP4 Signaling Expands Potency of Mouse Embryonic Stem Cells in Serum-Free Media.   Stem Cell Reports (2020), https://doi.org/10.1016/j.stemcr.2020.01.004(IF=5.499)

 

2018年:

Changshan Wang*, Motohiko Oshima, Daisuke Sato, Hirotaka Matsui, Sho Kubota, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Shuhei Koide, Jun Matsubayashi, Makiko Mochizuki-Kashio, Takako Nakano-Yokomizo, Jie Bai, Toshitaka Nagao, Akinori Kanai, Atsushi Iwama, and Goro Sashida. Ezh2 loss promotes transformation of early T-cell precursors by propagating pathogenic DNA hyper-methylation at T-cell developmental regulator gene.  Journal of Clinical Investigation. 2018.Aug 31;128 (9):3872-3886. doi: 10.1172/JCI94645. (IF=13.251)

 

2017年:

Zhenfei Wang, Daguang Ma, Changshan Wang*, Zhe Zhu, Yongyan Yang, Fenfang Zeng, Jianlong Yuan, Xia Liu, Yue Gao, Yongxia Chen, yongfeng jia. Triptonide inhibits the pathological functions of gastric cancer-associated fibroblasts.  Biomedicine & Pharmacotherapy. 2017 Oct 16;96:757-767. doi:10.1016（IF=3.457）

Masafumi Seki, Shunsuke Kimura, Tomoya Isobe, Kenichi Yoshida, Hiroo Ueno, Yaeko Nakajima-Takagi, Changshan Wang*, Lin Lin, Ayana Kon, Hiromichi Suzuki, Yusuke Shiozawa, Keisuke Kataoka, Yoichi Fujii, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Teppei Shimamura, Kyoko Masuda, Hiroshi Kawamoto, Kentaro Ohki, Motohiro Kato, Yuki Arakawa, Katsuyoshi Koh, Ryoji Hanada, Hiroshi Moritake, Masaharu Akiyama, Ryoji Kobayashi, Takao Deguchi, Yoshiko Hashii, Toshihiko Imamura, Atsushi Sato, Nobutaka Kiyokawa, Akira Oka, Yasuhide Hayashi, Masatoshi Takagi, Atsushi Manabe, Akira Ohara, Keizo Horibe, Masashi Sanada, Atsushi Iwama, Hiroyuki Mano, Satoru Miyano, Seishi Ogawa, & Junko Takita1. Recurrent PU.1 fusions in high-risk pediatric T cell acute lymphoblastic leukemia.  Nature genetics. online 03 July 2017. doi:10.1038/ng.3900（IF=27.959）

Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang*, Tetsuhiro Chiba, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama. Dual inhibition of EZH2 and EZH1 sensitizes PRC2-dependent tumors to proteasome inhibition.  Clinical cancer research. May 10, 2017  doi: 10.1158/1078-0432.CCR-16-2735（IF=10.199）

 

2016年：

Nagisa Hasegawa, Motohiko Oshima, Goro Sashida, Hirotaka Matsui, Shuhei Koide, Atsunori Saraya, Changshan Wang*, Tomoya Muto, Kiyoko Takane, Atsushi Kaneda, Kazuya Shimoda, Chiaki Nakaseko, Koutaro Yokote, and Atsushi Iwama. Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.  Leukemia 2016 Oct doi: 10.1038/leu.2016.268.（IF=11.702）

Goro Sashida^#, Changshan Wang^#*, Takahisa Tomioka, Motohiko Oshima, Kazumasa Aoyama, Akinori Kanai, Makiko Mochizuki-Kashio, Hironori Harada, Kazuya Shimoda, and Atsushi Iwama. The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.  Journal of Experimental Medicine. 2016; 213(8): 1459-77.  ^# equal contribution（IF=11.991）

Motohiko Oshima, Nagisa Hasegawa, Makiko Mochizuki-Kashio, Tomoya Muto, Satoru Miyagi, Shuhei Koide, Shogo Yabata, George Russel Wendt, Atsunori Saraya, Changshan Wang*, Kazuya Shimoda, Yutaka Suzuki, Atsushi Iwama. Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells.  Experimental Hematology. 2016 Apr;44(4):282-296.e3.（IF=2.82）

 

2015年：

Makiko Mochizuki-Kashio, Kazumasa Aoyama, Goro Sashida, Motohiko Oshima, Takahisa Tomioka, Tomoya Muto, Changshan Wang*, and Atsushi Iwama.  Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignanciesin an Ezh1-depenedent manner.  Blood.  2015; 126(10): 1172-83.（IF=13.164）

Changshan Wang*, Motohiko Oshima, Goro Sashida, Takahisa Tomioka, Nagisa Hasegawa, Makiko Mochizuki-Kashio, Yaeko Nakajima-Takagi, Yoichiro Kusunoki, Seishi Kyoizumi, Kazue Imai, Kei Nakachi, Atsushi Iwama. Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice.  PLoS One.  2015 Jul 10;10 (7):e0132041.（IF=.806）

 

2014年：

Yuta Mishima^#, Changshan Wang ^#*, Satoru Miyagi ^#, Atsunori Saraya^#, Hiroyuki Hosokawa, Makiko Mochizuki-Kashio, Yaeko Nakajima-Takagi, Shuhei Koide, Masamitsu Negishi, Goro Sashida, Taku Naito, Tomoyuki Ishikura, Atsushi Onodera, Toshinori Nakayama, Daniel G. Tenen, Naoto Yamaguchi, Haruhiko Koseki, Ichiro Taniuchi & Atsushi Iwama. Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.  Nature Communications. 2014; 5: 5872.^# equal contributions（IF=12.124）

Changshan Wang*, Goro Sashida, Atsunori Saraya, Reiko Ishiga, Shuhei Koide, Motohiko Oshima, Kyoichi Isono, Haruhiko Koseki, and Atsushi Iwama.   Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia.  Blood. 2014;123(21): 3336-43.（IF=13.164）

Goro Sashida, Hironori Harada, Hirotaka Matsui, Motohiko Oshima, MakikoYui, Yuka Harada, Satomi Tanaka, Makiko Mochizuki-Kashio, Changshan Wang*, Atsunori Saraya, Tomoya Muto,Yoshihiro Hayashi, Kotaro Suzuki, Hiroshi Nakajima, Toshiya Inaba, Haruhiko Koseki, Gang Huang, Toshio Kitamura & Atsushi Iwama. Ezh2 loss promotes RUNX1 mutant-induced myelodysplastic syndrome in cellintrinsic and extrinsic manners.  Nature communications. 5:4177. doi: 10.1038/ncomms5177. （IF=12.124）

Satoru Miyagi, Shuhei Koide, GeorgeR. Wendt, Motohiko Oshima, Takaaki Konuma, Satoshi Yamazaki, Makiko Mochizuki-Kashio,Yaeko Nakajima-Takagi, Changshan Wang*, Tetsuhiro Chiba, IssayKita bayashi, Hiromitsu Nakauchi, and Atsushi Iwama. The Tif1b -Hp1 system maintains transcriptional integrity of hematopoietic stem cells.  Stem Cell Reports. 2014 Jan 23;2(2):145-52.（IF=7.338）

Yuki Hayashi, Takao Kuroda, Hiroyuki Kishimoto, Changshan Wang*, Atsushi Iwama, Keiji Kimura. Downregulation of rRNA transcription triggers cell differentiation.  PLoS ONE 9:e98586, 2014. （IF=2.806）

 

2007年～2013年：

Changshan Wang*, Shunsuke Nakamura, Motohiko Oshima, Makiko Mochizuki-Kashio, Yaeko Nakajima-Takagi, Mitsujiro Osawa ,Yoichiro Kusunoki , Seishi Kyoizumi , Kazue Imai , Kei Nakachi and Atsushi Iwama. Compromised hematopoiesis and increased DNA damage following non-lethal ionizing radiation of a human hematopoietic system reconstituted in immunodeficient mice.  International Journal of Radiation Biology. 89, 132-137, 2013, Feb. （IF=1.992）

Taito Nishino, Changshan Wang*, Makiko Mochizuki-Kashio, Mitsujiro Osawa, Hiromitsu Nakauchi, Atsushi Iwama. Ex vivo expansion of human hematopoietic stem cells by Garcinol, a potent inhibitor of histone acetyltransferase.  PLoS ONE. 6: e24298, 2011（IF=2.806）

Yusuke Takeda, Chiaki Nakaseko, Hiroaki Tanaka, Masahiro Takeuchi, Makiko Yui, Atsunori Saraya, Satoru Miyagi, Changshan Wang*, Satomi Tanaka, Chikako Ohwada, Emiko Sakaida, Naoto Yamaguchi, KoutaroYokote, Lothar Hennighausen and Atsushi Iwama. Direct activation of STAT5 by ETV6-Lyn fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis.  British Journal of Hematology. 153, 589-598, 2011. （IF=5.67）

Shunsuke Suzuki, Ryuichi Ono, Takanori Narita, Andrew J. Pask, Geoffrey Shaw, Changshan Wang*, Takashi Kohda, Amber E. Alsop, Jennifer A. Marshall Graves,YujiKohara, Fumitoshi Ishino, Marilyn B. Renfree, Tomoko Kaneko-Ishino. Retrotransposon Silencing by DNA Methylation Can Drive Mammalian Genomic Imprinting.   PLoS Genetics.2007 Apr 13;3 (4) （IF=6.1）