莫日根（Morigen），1984年7月毕业于tyc1286太阳成集团植物学专业，获学士学位；2005年3月毕业于挪威奥斯陆大学分子生物学专业，获博士学位；2005年4月至2009年9月在挪威肿瘤医院癌症研究所做博士后研究。2009年10月回国任tyc1286太阳成集团生物化学与分子生物学教授、博士生导师，2010年10月至2020年3月任44118太阳成城集团副经理、经理，提出“立足草畜、旁及医药、创建一流”的办学方针。

现任内蒙古自治区细胞分子调控重点实验室主任、内蒙古自治区细胞分子工程技术研究中心主任。兼任内蒙古生物化学与分子生物学会理事长、中国细胞生物学会理事、《高校生物学教学研究（电子版）》《中国细胞生物学学报》《中国生物化学与分子生物学报》编委、《Frontiers in Microbiology》Topic Editor。

国家级一流本科分子生物学课程负责人、内蒙古自治区生物化学系列课程教学团队负责人。提出“以立德树人为本、重能力、求创新、国际化、个性化培养”的教学理念，创建并实践“多维度立体化生命科学本科创新人才培养体系”，实践科学史和问题导向的教学方法，提出了一系列独到见解和看法，发表教学研究论文19篇。获高等教育类内蒙古自治区教学成果一等奖和三等奖各1项

 

Email：morigenm@imu.edu.cn

 

一、研究领域和兴趣：

1. 细菌基因组稳定与演化机制。主要以大肠杆菌为模式生物，研究DNA复制与基因组稳定、细胞周期和基因表达调控机制，揭示细胞环境适应性和耐药性分子机理。

2. 肿瘤细胞DNA复制与基因组稳定以及细胞衰老。

 

Research interests:

1. The Escherichia coli DNA replication, cell cycle and environmental adaptation.

2. DNA replication in cancer cells.

 

二、相关学术论文：

26. Wu D, Baigalmaa L, Yao Y, Li G, Su M*, Fan L*, Morigen*

The Escherichia coli QseB/QseC signaling is required for correct timing of replication initiation and cell motility , Gene, doi: 10.1016/j.gene.2020.145374, 2020.

25. Ma J, Morigen*

TERRA-mediated telomere maintenance, Prog Biochem Biophys, accepted, 2020.

24. Dong Q, Qiao J, Sun H, Fan L, Morigen*

The replication transcription collision-based mutations and evolutionary implications, Prog Biochem Biophys, 47(11): 1162~1173, 2020.

23. Huang T, Yuan H, Fan L,Morigen*

H-NS, IHF, and DnaA lead to changes in nucleoid organizations, replication initiation, and cell division, J Basic Microbiol, DOI: 10.1002/jobm.201900497, 60:136-148, 2020.

22. Wurihan, Gezi, Brambilla E, Wang S, Sun H, Fan L, Shi Y1, Sclavi B*, Morigen*

DnaA and LexA proteins regulate transcription of the uvrB gene in Escherichia coli: the role of DnaA in the control of the SOS regulon, Front Microbiol, 9:1212, https://doi.org/10.3389/fmicb.2018.01212, 2018.

21. Yao Y, Enkhtsetseg S, Odsbu I, Fan L, Morigen*

Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1–1 plasmid, BMC Microbiol, 18:27 https://doi.org/10.1186/s12866-018-1162-3, 2018.

20. Zhang S, Wunier, Yao Y, Morigen*

Defects in ribosome function delay the initiation of chromosome replication in Escherichia coli, J Basic Microbiol, doi: 10.1002/jobm.201800295, 2018.

19. Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen*

The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis, Oncotarget, doi:10.18632/oncotarget.16872, 2017.

18. Yao Y, Fan L, Shi Y, Odsbu I, Morigen*

A spatial control for correct timing of gene expression during the Escherichia coli cell cycle, Genes, 8(1), 1: doi:10.3390/genes8010001, 2017.

17. Wurihan, Wunier, Li H, Fan L, Morigen*

Trans-translation ensures timely initiation of DNA replication and DnaA synthesis in Escherichia coli, Gent Mol Res, 15 (3): gmr.15038407, 2016.

16. Yao Y, Wunier, Morigen*

Absence of the BaeR protein leads to the early initiation of DNA replication in Escherichia coli, Gent Mol Res, 14(4):16888-16895, 2015.

15. Fan L, Yan H, Pellegrin S, Morigen*, H Mellor*

The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction, Neurosci Lett, 590(-):178-183, 2015.

14. Dong Q, Dong A, Morigen*

Evaluation of novel antibacterial N-halamine nanoparticles prodrugs towards susceptibility of Escherichia coli induced by DksA protein, Molecules, 21;20(4):7292-308, 2015.

13. Liu F, Qimuge, Hao J, Yan H, Bach T, Fan L, Morigen*

AspC-mediated aspartate metabolism coordinates the Escherichia coli cell cycle, PLoS ONE, 9(3):e92229, 2014.

12. Morigen*, Flatten I, K Skarstad*

The Escherichia coli datA site promotes proper regulation of cell division, SGM-Microbiol, 160(4):703-710, 2014.

11. Johnsen L, Flåtten I, Morigen*, Dalhus B, Bjørås M, Waldminghaus T, K Skarstad*

The G157C mutation in the Escherichia coli sliding clamp specifically affects initiation of replication, Mol Microbiol, 79(2):433-446, 2011.

10. Weatherspoon-Griffin N, Zhao G, Kong W, Kong Y, Morigen*, Andrews-Polymenis H, McClelland M, Y Shi*

The CpxR/CpxA two-component system up-regulates two Tat-dependent peptidoglycan amidases to confer bacterial resistance to antimicrobial peptide,J Biol Chem, 286(7):5529-39, 2011.

9.  Morigen*, Odsbu I, K Skarstad*

Growth rate dependent numbers of SeqA structures organize the multiple replication forks in rapidly growing Escherichia coli, Genes Cells,14(5):643-657, 2009.

8. Wang J*, Morigen*

BayesPI--a new model to study protein-DNA interaction: a case study of condition-specific protein binding parameters for yeast transcription factors, BMC Bioinformatics, 10:345, 2009.

7. Odsbu I., Morigen, K Skarstad*

A reduction in ribonucleotide reductase activity slows down the chromo some replication fork but does not change its localization, PLoS ONE, 4(10):e7617, 2009.

6. Flåtten I, Morigen, K Skarstad*

DnaA protein interacts with RNA polymerase and protects it from the effect of rifampicin,Mol Microbiol, 71(4):1018-1030, 2009.

5. Bach T, Morigen, K Skarstad*

The initiator protein DnaA contributes to keeping new origins inactivated by promoting the presence of hemimethylated DNA, J Mol Biol, 384(5):1076-85, 2008.

4. Morigen, Molina F, K Skarstad*

Deletion of the datA site does not affect once-per-cell-cycle timing but induces rifampin-resistant replication,J Bacteriol, 187(12):3913-20, 2005.

3. Morigen, Løbner-Olesen A, K Skarstad*

Titration of the Escherichia coli DnaA protein to excess datA sites causes destabilization of replication forks, delayed replication initiation and delayed cell division, Mol Microbiol, 50:349-362, 2003.

2. Morigen, Boye E, Skarstad K, A Løbner-Olesen*

Regulation of chromosomal replication by DnaA protein availability in Escherichia coli: effects of the datA region, Biochim Biophys Acta, 1521: 73-80, 2001.

1. Weigel C, Messer W*, Preiss S, Welzeck M, Morigen, E Boye

The sequence requirements for a functional Escherichia coli replication origin are different for the chromosome and a minichromosome, Mol Microbiol, 40(2): 498-507, 2001.