王进特聘研究员简介

姓名:王进

出生年月:198202

学位/学历:博士研究生    

职称:正高级

导师:博士生导师        

研究方向(领域):生物化学与分子生物学核酸生物化学,表观转录组学

学术(社会)兼职: 国家自然科学基金委基金评议专家、中国生物化学与分子生物学学会 RNA 专业委员会青委会委员、内蒙古生物化学与分子生物学会理事捷克科学基金会基金评审专家

联系方式:jinwang@imu.edu.cn    


1.学习(工作)经历

学习经历:

(1) 2005-112009-07, 香港浸会大学, 生物无机化学与生物物理化学, 博士

(2) 2001-092005-06, 武汉大学, 化学基地班, 学士

工作经历:

(1) 2018-10至现在, 44118太阳成城集团、省部共建草原家畜生殖调控与繁育国家重点实验室, 研究员

(2) 2015-012018-11, 麻省理工学院 SMARTSingapore-MIT Alliance for Research and Technology)中心,研究科学家(Research Scientist

(3) 2012-092014-12, 麻省理工学院 SMART 中心,博士后

(4) 2009-072012-07, 加州大学河滨分校,博士后

(5) 2004-082005-07, 香港浸会大学, 本科交换生


2.表彰奖励

入选第十一批内蒙古自治区草原英才工程,2021


3.人才培养

承担tyc1286太阳成集团本科生的生物化学及生物工程前沿进展等课程的教学工作,培养博士研究生4名(在读4名)硕士研究生7名(毕业2名,在读5名)。


4.科研成果

主持的科研项目:

1. 国家自然科学基金地区项目,31960140RNA 5' 端帽表观转录组定量分析及其调控机制研究,2020.01-2023.1240万,在研。

2. 内蒙古自治区科技重大专项子课题项目,RNA 端帽表观转录组与蛋白质糖基化修饰分析技术揭示动物早期胚胎发育机制研究,2020ZD0008(子课题),2020.01-2022.1254.25万,在研。

3. 2018年度内蒙古自治区本级引进高层次人才科研支持项目,2020.01-2022.1240万,在研。

4. 内蒙古自治区草原英才科研基金项目,2021.03-2023.1210万,在研。

5. 内蒙古自治区杰出青年培育基金项目,基于质谱技术的核酸生物化学研究,2021JQ032021.01-2023.1230万,在研。

6. 中央引导地方科技发展资金项目,胚胎干细胞及其分化过程中的mRNA 5' 端帽修饰,12814061506962391042020.01-2021.1220万,已结题。

7. tyc1286太阳成集团省部共建草原家畜生殖调控与繁育国家重点实验室自主课题,人类细胞和动物精子中tRNA衍生RNA片段tRFs)修饰图谱的绘制, SKL-IT-2018302019.10-2021.1250万,已结题。

8. tyc1286太阳成集团骏马计划引进人才科研启动金,2019.01-2021.12300万。

科研论文

所有共同第一作者均加注上标#字样,通讯作者及共同通讯作者均加注上标 *字样

1. J. Wang*, B. L. A. Chew, Y. Lai, H. Dong, L. Xu, S. Balamkundu, W. M. Cai, L. Cui, C. F. Liu, X.-Y. Fu, Z. Lin, P.-Y. Shi, T. K. Lu, D. Luo, S. R. Jaffrey, P. C. Dedon* (2019) Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA. Nucleic Acids Res., 47, e130.

2. A. R. Robinson#, M. J. Yousefzadeh#, T. A. Rozgaja#, J. Wang, et al. E. E. Kelley*, L. J. Niedernhofer* (2018) Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biol. 17, 259-273.

3. J. Wang, H. Dong, Y. H. Chionh, M. E. McBee, S. Sasilada, P.-Y. Shi, P. C.

Dedon* (2016) The role of sequence context, nucleotide pool balance and stress in 2'-deoxynucleotide misincorporation in viral, bacterial and mammalian RNA. Nucleic Acids Res. 44, 8962-8975.

4. N. E. Price, K. M. Johnson, J. Wang, M. I. Fekry, Y. Wang, K. S. Gates* (2014) Interstrand DNA-DNA cross-link formation between adenine residues and abasic sites in duplex DNA. J. Am. Chem. Soc. 136, 3483-3490.

5. S. Liu, J. Wang, Y. Su, C. Guerrero, Y. Zeng, D. Mitra, P. J. Brooks, D. E. Fisher, H. Song, Y. Wang* (2013) Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA. Nucleic Acids Res. 41, 6421-6429.

6. K. M. Johnson, N. E. Price, J. Wang, M. I. Fekry, S. Dutta, D. R. Seiner, Y. Wang, K. S. Gates* (2013) On the formation and properties of interstrand DNA-DNA cross-links forged by reaction of an abasic site with the opposing guanine residue of 5'-CAp sequences in duplex DNA. J. Am. Chem. Soc. 135, 1015-1025.

7. C. R. Guerrero, J. Wang, Y. Wang* (2013) Induction of 8,5'-cyclo-2' -deoxyadenosine and 8,5'-cyclo-2'-deoxyguanosine in isolated DNA by Fenton-type reagents. Chem. Res. Toxicol. 26, 1361-1366.

8. J. Wang, H. Cao, R. Bahde, S. Gupta, C. Nishigori, P. J. Brooks, L. J. Niedernhofer, Y. Wang* (2012) Endogenous formation and repair of oxidatively induced G[8-5m]T intrastrand cross-link lesion. Nucleic Acids Res. 40, 7368-7374.

9. J. S. Tilstra# , A. R. Robinson# , J. Wang# , S. Q. Gregg# , C. L. Clauson# , D. P. Reay, L. A. Nasto, C. M. St Croix, A. Usas, N. Vo, J. Huard, P. R. Clemens, D. B. Stolz, D. C. Guttridge, S. C. Watkins, G. A. Garinis, Y. Wang, Laura J. Niedernhofer*, Paul D. Robbins* (2012) NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J. Clin. Invest. 122, 2601-2612. 入选前1% ESI 高被引论文(2012-2021

10. J. Wang, C. L. Clauson, P. D. Robbins, L. J. Niedernhofer, Y. Wang* (2012) The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner. Aging Cell 11, 714-716.

11. D. Mitra, X. Luo, A. Morgan, J. Wang, M. P. Hoang, J. Lo, C. R. Guerrero, J. K. Lennerz, M. C. Mihm, J. A. Wargo, K. C. Robinson, S. P. Devi, J. C. Vanover, J. A. D’Orazio, M. McMahon, M. W. Bosenberg, K. M. Haigis, D. A. Haber, Y. Wang, D. E. Fisher* (2012) An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature 491, 449-453.

12. C. You, X. Dai, B. Yuan, J. Wang, J. Wang, P. J. Brooks, L. J. Niedernhofer, Y. Wang* (2012) A quantitative assay for assessing the effects of DNA lesions on transcription. Nat. Chem. Biol. 8, 817-822.

13. H. Shaked, L. J. Hofseth, A. Chumanevich, A. A. Chumanevich, J. Wang, Y. Wang, K. Taniguchi, M. Guma, S. Shenouda, H. Clevers, C. C. Harris, M. Karin* (2012) Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc. Natl. Acad. Sci. USA 109, 14007-14012.

14. L. J. Cliffe, G. Hirsch, J. Wang, D. Ekanayake, W. Bullard, M. Hu, Y. Wang, R. Sabatini* (2012) JBP1 and JBP2 proteins are Fe2+/2-oxoglutarate-dependent dioxygenases regulating hydroxylation of thymidine residues in trypanosome DNA. J. Biol. Chem. 287, 19886-19895.

15. J. Wang, B. Yuan, C. R. Guerrero, R. Bahde, S. Gupta, Y. Wang* (2011)

Quantification of oxidative DNA lesions in tissues of Long-Evans Cinnamon rats by capillary high-performance liquid chromatography-tandem mass spectrometry coupled with stable isotope-dilution method. Anal. Chem. 83, 2201-2209.

著作章节

Y. Liu, J. Wang* (2021) Isotope-dilution liquid chromatography-tandem mass

spectrometry for detection of 5-hydroxymethyluracil and 5-formyluracil in DNA. In: Yuan, B-F (Ed). DNA Modification Detection Methods. Springer Protocols Handbooks, Springer US, pp 129-139.


5.发明专利


6.相片:

 

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