主持的科研项目：

1. 国家自然科学基金地区项目，31960140，RNA 5' 端帽表观转录组定量分析及其调控机制研究，2020.01-2023.12，40万，在研。

2. 内蒙古自治区科技重大专项子课题项目，RNA 端帽表观转录组与蛋白质糖基化修饰分析技术揭示动物早期胚胎发育机制研究，2020ZD0008（子课题），2020.01-2022.12，54.25万，在研。

3. 2018年度内蒙古自治区本级引进高层次人才科研支持项目，2020.01-2022.12，40万，在研。

4. 内蒙古自治区“草原英才”科研基金项目，2021.03-2023.12，10万，在研。

5. 内蒙古自治区杰出青年培育基金项目，基于质谱技术的核酸生物化学研究，2021JQ03，2021.01-2023.12，30万，在研。

6. 中央引导地方科技发展资金项目，胚胎干细胞及其分化过程中的mRNA 5' 端帽修饰，1281406150696239104，2020.01-2021.12，20万，已结题。

7. tyc1286太阳成集团省部共建草原家畜生殖调控与繁育国家重点实验室自主课题，人类细胞和动物精子中tRNA衍生RNA片段（tRFs)修饰图谱的绘制， SKL-IT-201830，2019.10-2021.12，50万，已结题。

8. tyc1286太阳成集团“骏马计划”引进人才科研启动金，2019.01-2021.12，300万。

科研论文

所有共同第一作者均加注上标“#”字样，通讯作者及共同通讯作者均加注上标 “*”字样

1. J. Wang*, B. L. A. Chew, Y. Lai, H. Dong, L. Xu, S. Balamkundu, W. M. Cai, L. Cui, C. F. Liu, X.-Y. Fu, Z. Lin, P.-Y. Shi, T. K. Lu, D. Luo, S. R. Jaffrey, P. C. Dedon* (2019) Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA. Nucleic Acids Res., 47, e130.

2. A. R. Robinson#, M. J. Yousefzadeh#, T. A. Rozgaja#, J. Wang, et al. E. E. Kelley*, L. J. Niedernhofer* (2018) Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biol. 17, 259-273.

3. J. Wang, H. Dong, Y. H. Chionh, M. E. McBee, S. Sasilada, P.-Y. Shi, P. C.

Dedon* (2016) The role of sequence context, nucleotide pool balance and stress in 2'-deoxynucleotide misincorporation in viral, bacterial and mammalian RNA. Nucleic Acids Res. 44, 8962-8975.

4. N. E. Price, K. M. Johnson, J. Wang, M. I. Fekry, Y. Wang, K. S. Gates* (2014) Interstrand DNA-DNA cross-link formation between adenine residues and abasic sites in duplex DNA. J. Am. Chem. Soc. 136, 3483-3490.

5. S. Liu, J. Wang, Y. Su, C. Guerrero, Y. Zeng, D. Mitra, P. J. Brooks, D. E. Fisher, H. Song, Y. Wang* (2013) Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA. Nucleic Acids Res. 41, 6421-6429.

6. K. M. Johnson, N. E. Price, J. Wang, M. I. Fekry, S. Dutta, D. R. Seiner, Y. Wang, K. S. Gates* (2013) On the formation and properties of interstrand DNA-DNA cross-links forged by reaction of an abasic site with the opposing guanine residue of 5'-CAp sequences in duplex DNA. J. Am. Chem. Soc. 135, 1015-1025.

7. C. R. Guerrero, J. Wang, Y. Wang* (2013) Induction of 8,5'-cyclo-2' -deoxyadenosine and 8,5'-cyclo-2'-deoxyguanosine in isolated DNA by Fenton-type reagents. Chem. Res. Toxicol. 26, 1361-1366.

8. J. Wang, H. Cao, R. Bahde, S. Gupta, C. Nishigori, P. J. Brooks, L. J. Niedernhofer, Y. Wang* (2012) Endogenous formation and repair of oxidatively induced G[8-5m]T intrastrand cross-link lesion. Nucleic Acids Res. 40, 7368-7374.

9. J. S. Tilstra# , A. R. Robinson# , J. Wang# , S. Q. Gregg# , C. L. Clauson# , D. P. Reay, L. A. Nasto, C. M. St Croix, A. Usas, N. Vo, J. Huard, P. R. Clemens, D. B. Stolz, D. C. Guttridge, S. C. Watkins, G. A. Garinis, Y. Wang, Laura J. Niedernhofer*, Paul D. Robbins* (2012) NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J. Clin. Invest. 122, 2601-2612. 入选前1% ESI 高被引论文（2012-2021）

10. J. Wang, C. L. Clauson, P. D. Robbins, L. J. Niedernhofer, Y. Wang* (2012) The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner. Aging Cell 11, 714-716.

11. D. Mitra, X. Luo, A. Morgan, J. Wang, M. P. Hoang, J. Lo, C. R. Guerrero, J. K. Lennerz, M. C. Mihm, J. A. Wargo, K. C. Robinson, S. P. Devi, J. C. Vanover, J. A. D’Orazio, M. McMahon, M. W. Bosenberg, K. M. Haigis, D. A. Haber, Y. Wang, D. E. Fisher* (2012) An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature 491, 449-453.

12. C. You, X. Dai, B. Yuan, J. Wang, J. Wang, P. J. Brooks, L. J. Niedernhofer, Y. Wang* (2012) A quantitative assay for assessing the effects of DNA lesions on transcription. Nat. Chem. Biol. 8, 817-822.

13. H. Shaked, L. J. Hofseth, A. Chumanevich, A. A. Chumanevich, J. Wang, Y. Wang, K. Taniguchi, M. Guma, S. Shenouda, H. Clevers, C. C. Harris, M. Karin* (2012) Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc. Natl. Acad. Sci. USA 109, 14007-14012.

14. L. J. Cliffe, G. Hirsch, J. Wang, D. Ekanayake, W. Bullard, M. Hu, Y. Wang, R. Sabatini* (2012) JBP1 and JBP2 proteins are Fe2+/2-oxoglutarate-dependent dioxygenases regulating hydroxylation of thymidine residues in trypanosome DNA. J. Biol. Chem. 287, 19886-19895.

15. J. Wang, B. Yuan, C. R. Guerrero, R. Bahde, S. Gupta, Y. Wang* (2011)

Quantification of oxidative DNA lesions in tissues of Long-Evans Cinnamon rats by capillary high-performance liquid chromatography-tandem mass spectrometry coupled with stable isotope-dilution method. Anal. Chem. 83, 2201-2209.

著作章节

Y. Liu, J. Wang* (2021) Isotope-dilution liquid chromatography-tandem mass

spectrometry for detection of 5-hydroxymethyluracil and 5-formyluracil in DNA. In: Yuan, B-F (Ed). DNA Modification Detection Methods. Springer Protocols Handbooks, Springer US, pp 129-139.