李佳智博士在攻克CRISPR-Cas获得性免疫系统未解决难题、探索tRNA甲基化转移酶工作机制和分子靶向药物筛选等方面作出了创新性工作。从蛋白质-核酸复合物的功能及生物学意义的研究视角出发，着眼于蛋白质/酶与核酸底物识别、互作和活性调节等分子机理，为探究关键的生物学过程、致病机理和基于生物大分子结构的药物研发提供了新的依据。以第一作者（含共同）在Cell、Nature和Nature Structural & Molecular Biology等期刊发表论文,研究成果在国内外学术界获得了高度评价和广泛关注。
代表论文：
Jiazhi Li*, Longfei Wang*, Quentin Hahn, Radosław P. Nowak, Thibault Viennet, Esteban Orellana, Shourya Sonkar Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric Fischer, and Richard I. Gregory. Structural basis of regulated m7G tRNA modification by METTL1-WDR4. Nature. 2023 Jan;613(7943):391-397. (* Co-first author)
Jiazhi Li, Gregory, R.I. Mining for METTL3 inhibitors to suppress cancer. Nat Struct Mol Biol 28, 460–462 (2021).
Yang Jing*, Jiazhi Li*, Jiuyu Wang, Gang Sheng, Min Wang, Hongtu Zhao, Yanhua Yang, and Yanli Wang. Crystal structure of Cas1 in complex with branched DNA. Science China Life Sciences 63, no. 4 (2020): 516-528 (* Co-first author)
Liang Liu, Xueyan Li, Jiuyu Wang, Min Wang, Peng Chen, Maolu Yin, Jiazhi Li, Gang Sheng, Yanli Wang. Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities. Cell. 2017 Jan 12;168(1-2):121-134
Jiuyu Wang*, Jiazhi Li*, Hongtu Zhao, Gang Sheng, Min Wang, Maolu Yin, and Yanli Wang. Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems. Cell. 2015 Nov 5;163(4):840-53 (* Co-first author)
蒙ICP16002391号-1 