科研项目

1.广东省基础与应用基础研究区域联合基金-青年基金项目，主持，在研。

2.国家自然科学基金青年项目，主持，在研。

3.tyc1286太阳成集团“骏马计划”B1高层次人才项目，主持，在研。

发表论文

1. Chen M^#, Wang N^#, Yang H^#, Liu D#, Gao Y, Duo L, Cui X, Hao F, Ye J, Gao F, Tu Q*, Gui Y*. Single-cell transcriptome analysis of the germ cells and somatic cells during mitotic quiescence stage in goats. FASEB J. 2023 Nov;37(11):e23244. doi: 10.1096/fj.202301278.

2. Chen M^#, Long X^#, Chen M^#, Hao F^#, Kang J, Wang N, Wang Y, Wang M, Gao Y, Zhou M, Duo L, Zhe X, He J, Ren B, Zhang Y, Liu B, Li J, Zhang Q, Yan L, Cui X, Wang Y, Gui Y, Wang H, Zhu L*, Liu D*, Guo F*, Gao F*. Integration of single- cell transcriptome and chromatin accessibility of early gonads development among goats, pigs, macaques, and humans. Cell Rep. 2022 Nov 1;41(5):111587. doi: 10.1016/j.celrep.2022.111587.

3. Chen M^#, Yao C^#, Qin Y^#, Cui X, Li P, Ji Z, Lin L, Wu H, Zhou Z, Gui Y*, Li Z*, Gao F*. Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing. Signal Transduct Target Ther. 2022 Jan 3;7(1):1. doi: 10.1038/s41392-021-00710-4.

4. Chen M, Gao F*. The Regulation of Gonadal Somatic Cell Differentiation in Humans. Genomics Proteomics Bioinformatics. 2022 Apr;20(2):219-222. doi: 10.1016/j.gpb.2022.04.003.

5. Song Y^#, Chen M^#, Zhang Y, Li J, Liu B, Li N, Chen M, Qiao M, Wang N, Cao Y, Lu S, Chen J, Sun W*, Gao F*, Wang H*. Loss of circSRY reduces γH2AX level in germ cells and impairs mouse spermatogenesis. Life Sci Alliance. 2022 Nov 22;6(2):e202201617. doi: 10.26508/lsa.202201617. (Equal contribution)

6. Chen M^#, Wang Y^#, Lin L, Dong F, Wu H, Bao S, Gao F*. PRMT7 is involved in regulation of germ cell proliferation during embryonic stage. Biochem Biophys Res Commun. 2020 Dec 17;533(4):938-944. doi: 10.1016/j.bbrc.2020.09.099.

7. Chen M^#, Chen M^#, Chen S, Zhou J, Dong F, Shen Z, Wu H, Cui X, Gao F*. Abnormal Meiosis Initiation in Germ Cell Caused by Aberrant Differentiation ofGonad Somatic Cell. Oxid Med Cell Longev. 2019 Sep 5;2019:8030697. doi: 10.1155/2019/8030697. (Equal contribution)